Question
Download Solution PDFThe highest nonzero dose at which no toxic effect is observed in a study on animals is called
Answer (Detailed Solution Below)
Detailed Solution
Download Solution PDFThe correct answer is the No observed adverse effect level (NOAEL)
Important Points
No Observed Adverse Effect Level (NOAEL)
- It is the highest exposure level at which there are no biologically significant increases in the frequency or severity of adverse effect between the exposed population and its appropriate control.
- Some effects may be produced at this level, but they are not considered adverse effects.
Additional Information
- LD50 (Lethal Dose 50%)
- It is a statistically derived dose at which 50% of the animals will be expected to die.
- For inhalation toxicity, air concentrations are used for exposure values.
Thus, the LC50 (Lethal Concentration 50%) is used
- Lowest Observed Adverse Effect Level (LOAEL)
- It is the lowest exposure level at which there are biologically significant increases in frequency or severity of adverse effects between the exposed population and its appropriate control group
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